Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
oleh: Yuefeng Tang, Martina Wallace, Joan Sanchez-Gurmaches, Wen-Yu Hsiao, Huawei Li, Peter L. Lee, Santiago Vernia, Christian M. Metallo, David A. Guertin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-04-01 |
Deskripsi
The kinase mTOR controls anabolic metabolism. Here, the authors create fat-specific mTORC2 knockout mice using the Adiponectin-Cre driver and show mTORC2 signalling is important for systemic metabolic homeostasis by controlling adipocyte de novolipogenesis and glucose uptake.