Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases
oleh: Miran Rada, Audrey Kapelanski-Lamoureux, Stephanie Petrillo, Sébastien Tabariès, Peter Siegel, Andrew R. Reynolds, Anthoula Lazaris, Peter Metrakos
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-08-01 |
Deskripsi
Miran Rada et al. identify a key role for RUNX1 in liver metastasis of colorectal cancer. They show that RUNX1 is necessary for driving blood vessel co-option from surrounding liver tissue and that regulation of this process relies on a signaling feedback loop between RUNX1 transcriptional target TSP1 in tumor cells and TGFβ1 in the liver.