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Previously, we analyzed 316 herbal extracts to evaluate their potential nematocidal properties in <i>Caenorhabditis elegans.</i> In this study, our attention was directed towards <i>Torenia sp</i>., resulting in reduced survival and heightened larval arrest/lethality, alongside a noticeable decrease in DAPI-stained bivalent structures and disrupted meiotic progression, thus disrupting developmental processes. Notably, <i>Torenia sp</i>. extracts activated a DNA damage checkpoint response via the ATM/ATR and CHK-1 pathways, hindering germline development. LC–MS analysis revealed 13 compounds in the <i>Torenia sp</i>. extracts, including flavonoids, terpenoids, tanshinones, an analog of resveratrol, iridoids, carotenoids, fatty acids, and alkaloids. Of these, 10 are known for their antitumor activity, suggesting the potential of <i>Torenia species</i> beyond traditional gardening, extending into pharmaceutical and therapeutic applications.