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Background: Perovskia abrotanoides is small kind of lamiaceae family that find in iran and some neighboring countries by endemic. Objective: Because The effect of anti-bacterial and anti-fungal medical plant extract on bacteria and fungi and determine the Minimal Inhibitory Concentration (MIC) has not been done so present study follow the above aim. Methodes: In this study by using 80% methanol, plant extract extracted and different concentrations of extract the by using DMSO solvent provided.Then studid the antimicrobial effect of plant extract on number of bacteria and fungi by Agar Dilution Method and compared the determined MIC with Gentamicin for bacteria and Nystatin for fungi. Results: Results obtained of anti-bacterial effects by Agar Dilution Method showed that the extract has inhibitory effect in 1,2,4 >32 mg/ml concentration for gram negative bacteria, in 0/125 mg/ml concentration for gram positive bacteria.Gentamicin has inhibitory effect in 0/25, 0/125,1mg/ml concentration for gram negative bacteria and in 0/25, 0/125 mg/ml concentration for gram positive bacteria.The desired extract in 1,2,4,8 mg/ml concentration and Nystatin in 0/0625, 0/125, 0/5, 1 mg/ml concentration have inhibitory effect on tested fungi. Conclusion: Perovskia abrotanoides herbal extract has compounds such as sesquiterpens and monoterpens that couse anti-bacterial and anti-fungal effect on desired pathogens.