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Microwave heating is one of the prominent treatment procedure that elevates body temperature using microwave energy to damage tumor cells. However, healthy tissues can also absorb microwave energy causing undesired damage. This research study focuses on optimizing the surrounding healthy tissue damage by diffusing magnetic nanoparticles (NPs) in the tumor region. A rectangular liver tissue is modeled using Finite Element Methods (FEM) and then a half-elliptical shaped tumor is incorporated in the model. A coaxial antenna covered with a polytetrafluoroethylene catheter is inserted at the edge of the liver tissue. Then the magnetic NPs are diffused within the tumor region. The performance of microwave heating with and without nanoparticle diffusion is compared using the performance parameters: power dissipation density, temperature distribution, and resultant tissue necrosis. Simulation results show that the heating procedure coupled with ferromagnetic nanoparticle diffusion has approximately 14% less damage to the healthy tissue. The study also shows that 433/915 MHz frequency value provides 3% less damage to the healthy tissue than 2.45 GHz. Analyzing the performance of different nanoparticle we found that the ferromagnetic nanoparticle provides 15% and 5% less damage to the healthy tissue than gold and manganese iron oxide NPs respectively. The obtained result was also verified for kidney, breast, and lung tumor ablations to confirm the findings.