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<p><em>Bacillus cereus </em>infection is rarely associated with actual infection and for this reason single positive blood culture is usually regarded as contamination . However it may cause a number of infections, such catheter-related blood stream infections. Significant catheter-related bloodstream infections (CRBSI) caused by <em>Bacillus spp</em>. are mainly due to <em>B.cereus</em> and have been predominantly reported in immunocompromised hosts<sup>1</sup> . Catheter removal is generally advised for management of infection. In this report, catheter-related bacteremia caused by <em>B.cereus</em> in a patient with acute lymphoblastıc leukemia (ALL) in Istanbul Medical Faculty was presented.A 44-year old man presented with fatigue, weight loss, epistaxis and high fever. A double-lumen Hickman–catheter (Bard 12.0 Fr, Round Dual Lumen) was inserted by surgical cut-down to access the right subclavian vein which would be necessary for allogeneic stem cell transplantation. Three weeks later the patient presented with high fever and headache. <em>Bacillus spp. </em>was isolated from the cathether while blood culture obtained from the peripheral vein remained negative. The bacterial identification was confirmed as <em>B.cereus</em> using VITEK identification system</p><p>It has been reported <em>Bacillus cereus </em>septicemia may be fatal in immunocompromised hosts despite broad-spectrum appropriate treatment<sup>10</sup>. Catheter removal is essential for prevention of recurrent bacteremia. Long-term cathater salvage should be reserved for appropriate patient group.</p>