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To study the phenomena of two-phase flow with salt crystallising in the chemical pump, the 3-D turbulent flow in the impeller of chemical pump was simulated at the condition of rinsing. The internal flow between the impellers of 1H65 chemical pump is investigated. Based on the Reynolds-averaging N-S equations and the standard k- two equations turbulent model, the simulations of turbulent flow between the impellers are performed using the flow computing software Fluent under different operating conditions. The calculation results are compared with the experimental data by particle image velocimetery (PIV). Based on the analysis of the calculated results of velocity and pressure profiles in the chemical pump and experimentally observed phenomenon of flow impact, secondary flow and recirculation, some design improvements are proposed, which give suggestions on the optimal design and internal two-phase flow study of the chemical pump.