Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
oleh: Nicholas G. Fox, Xiaodi Yu, Xidong Feng, Henry J. Bailey, Alain Martelli, Joseph F. Nabhan, Claire Strain-Damerell, Christine Bulawa, Wyatt W. Yue, Seungil Han
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-05-01 |
Deskripsi
The iron-sulfur cluster (ISC) assembly complex is activated by frataxin (FXN) and Friedreich’s ataxia is caused by FXN deficiency. Here the authors present the 3.2 Å resolution cryo-EM structure of the human frataxin bound ISC complex and discuss how FXN activates enzymatic activity.