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This work aims to derive new inequalities that improve the asymptotic and oscillatory properties of solutions to fourth-order neutral differential equations. The relationships between the solution and its corresponding function play an important role in the oscillation theory of neutral differential equations. Therefore, we improve these relationships based on the modified monotonic properties of positive solutions. Additionally, we set new conditions that confirm the absence of positive solutions and thus confirm the oscillation of all solutions of the considered equation. We finally explain the importance of the new inequalities by applying our results to some special cases of the studied equation, as well as comparing them with previous results in the literature.