Thermostable exoshells fold and stabilize recombinant proteins
oleh: Siddharth Deshpande, Nihar D. Masurkar, Vallerinteavide Mavelli Girish, Malan Desai, Goutam Chakraborty, Juliana M. Chan, Chester L. Drum
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-11-01 |
Deskripsi
Improving recombinant protein expression and stabilization remains a significant challenge. Here, the authors engineer Archaeoglobus fulgidus ferritin as a thermostable exoshell to provide steric accommodation and charge complementation for recombinant proteins, which can improve yields by 100 fold.