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Introduction The aim of the present study was to examine the protective effect aqueous extract of red Crataegus pentaegyna after high intensity running training on cardiac injury biomarkers in male rats. Materials and Methods Twenty Wistar male rats, 140-173 g weight, were randomly classified into saline-control (SC), saline-training (ST), Crataegus-Pentaegyna -control (CPC), and Crataegus-Pentaegyna -training (CPT) groups. Training groups have performed a high-intensity running program (34 m/min, 60 min/day, 5 days/week) on a motor-driven treadmill for eight weeks. The CPC and CPT groups were orally fed with Crataegus-Pentaegyna extraction (500mg/kg) and the same amount of saline was given to the SC and ST groups. The rats were sacrificed seventy- two hours after the last training session. Then, the heart tissue was excised and immediately frozen in liquid nitrogen and stored at -80 °C. The plasma was also collected for measuring the biomarkers. Statistical analysis was performed using a one way analysis of variance, and significance was accepted at p< 0.05. Results The results showed the high intensity running significantly increased the levels of cTnI, LDH and CK in heart and plasma of rats. The levels of cTnI, LDH and CK in a CPC in heart and plasma were significantly decreased versus the ST group. Conclusion Our findings showed that a Red Crataeguse-Pentaegyna may prevent the cardiac injury biomarkers in rats as a result of intensity endurance training.