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The aim of the project was to create a computer program, an expert system (ES), which would support physicians when a management for patients with acute coronary syndrome needs to be chosen. A knowledge database was created with the support of clinical experts, based on the current management standards. Data from new patients are added to the case database. The inference engine integrates two types of reasoning rule-based and case-based. The ES gives unambiguous and objective answers, its recommendation are reliable. At present, the ES is tested in clinical practice. Strategies recommended by the ES are compared with the management applied in a clinic.