Association of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies
oleh: Terry E. Goldberg, Edward D. Huey, D. P. Devanand
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-09-01 |
Deskripsi
The apolipoprotein E (APOE) gene contains both the major common risk variant associated with clinically diagnosed late onset Alzheimer’s disease (AD), APOE e4, and a neuroprotective variant, APOE e2. Here the authors confirm that the e2 allele is protective against Alzheimer’s disease neuropathologies, but show that it is not protective against other neurodegenerative disorders.