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<p><strong>Background: </strong>Suicide is a complicated phenomenon which is influenced by the interaction of psychological and environmental factors. The aim of this study was to investigate rate of depression disorders in suicide attempters with drug or toxins in the Baharloo hospital, Tehran, Iran, duration 1394.</p><p><strong>Materials and Methods:</strong> In this cross-sectional descriptive study, Beck Depression standardized questionnaire and demographic/socioeconomic information form was given to 248 suicide cases with drug or toxins to fill completely. For analyzing the data, Chi- Square and Multiple logistic regression tests were executed by spss_19.</p><p><strong>Results: </strong>In this study, from 248 cases hospitalized due to suicide attempt with drugs or toxins, 87.2% diagnosed with depressive disorders. In chi²analysis there was significant association between depression disorders and these variables “married status (p=0.001), housewife (p=0.002), family monthly income below 10000000 Rials<a title="" href="file:///C:/Users/narges/Downloads/article.docx#_ftn1">[1]</a> (p=0.005), substance use (p=0.001), psychiatric disorders history (p=0.001)”. In full model multiple logistic regression analysis (total variables entered in model) we found significant association between depressive disorders and "   gender, woman (p=0.03, OR=6.2, 95%CI= 1.33-3.44), aged 25-15 years (p=0.002, OR=22.7, 95%CI= 3.16-154.9), married status (p=0.007, OR=10.2, 95%CI= 1.87-55.5), worker or self-employment (p=0.02, OR=15.66, 95%CI= 1.41-172.25), (p=0.02, OR=14.97, 95%CI= 1.32-162.5)  and family monthly income below ten million Rails (p&lt;0.001, OR=11.30, 95%CI= 3.16-40.8) ".  Also, family monthly income below 10000000 Rials (p&lt;0.001, OR=5.34, 95%CI= 2.05-13.91), married status and divorced or widow/widower (p&lt;0.001, OR=3.93, 95%CI= 11.5-33.74), (p=0.01, OR=3.27, 95%CI= 16.57-83.71), age 15-25 and 26-35 (p=0.02, OR=9.15, 95%CI= 2.32-36.08),(p=0.01, OR=5.34, 95%CI= 1.36-21.03) are predictor factors for depression disorders leading to suicide attempt.</p><p><strong>Conclusion: </strong>Future planning should focus on premature diagnosis of psychiatric disorders particular depression disorders because of first cause of suicide. This aim will be achieved through continuous consulting and following vulnerable cases.</p><p><strong>Keywords:</strong> Depressive disorders, suicide, drug or toxins<strong></strong></p><div> </div>