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Confluent and reticulated papillomatosis (CRP) was first described in 1927 by Gougerot and Carteaud. It is characterized by papules that become confluent in the center and reticulated at the periphery. The etiology and pathogenesis of CRP are not precisely known and there is no standard therapy for it. In the recent cases reported, treatment of choice is minocycline. In this report, we present two cases of CRP responding well to Chinese drug, Jianpizhiyang. Some elements in Jianpizhiyang granula were thought to have anti-inflammatory. We expect that, which always has little side-effect, will be a good choice for CRP.