Preparation of a Key Intermediate for the Angiotensin II Antagonist Losartan via Vilsmeier Chloroformylation
oleh: Gareth J. Griffiths
| Format: | Article |
|---|---|
| Diterbitkan: | Swiss Chemical Society 1997-06-01 |
Deskripsi
A novel preparation of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde, a key intermediate for the synthesis of the angiotensin II antagonist Losartan potassium, via Vilsmeier chloroformylation of imidazolinone is described.