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Chryseobacterium indologenes is a rare pathogen of the humans and is normally found in the environment in soil, plants and foodstuffs. Infections caused by C. indologenes have been reported as a cause of serious infections in adult immune-compromised patients and in patients with indwelling catheters. We report a case of a 63-year-old man with oesophageal cancer who underwent surgery at our institute and developed C.indologenes bacteraemia almost a month after the operation. Our study reiterates the fact that severe underlying disease, long duration of broadspectrum antibiotics and invasive devices can be risk factors for developing bacteraemia from novel pathogens such as C.indologenes.