Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic <i>Caenorhabditis elegans</i>
oleh: Aleen D Saxton, Brian C Kraemer
| Format: | Article |
|---|---|
| Diterbitkan: | Oxford University Press 2021-05-01 |
Deskripsi
AbstractAmyotrophic lateral sclerosis (ALS) is a debilitating, fatal neurodegenerative disease that causes rapid muscle wasting. It shares a spectrum of symptoms and pathology with frontotemporal lobar degeneration (FTLD). These diseases are caused by aberrant activity of a set of proteins including TDP-43 and UBIQUILIN-2 (UBQLN2). UBQLN2Caenorhabditis elegansC. eleganstdp-1