Comprehensive Immune Profiling of a Kidney Transplant Recipient With Peri-Operative SARS-CoV-2 Infection: A Case Report
oleh: Karen R. Sherwood, Karen R. Sherwood, David D. M. Nicholl, Franz Fenninger, Vivian Wu, Paaksum Wong, Vince Benedicto, Davide P. Cina, Meng Wang, Taylor D. Pobran, Mari L. De Marco, Mari L. De Marco, Anna Citlali Márquez, Agatha N. Jassem, Agatha N. Jassem, Inna Sekirov, Inna Sekirov, Muhammad G. Morshed, Muhammad G. Morshed, Mohammad Bardi, Mohammad Bardi, Mypinder Sekhon, Paul Keown, Paul Keown, Matthew Kadatz, Matthew Kadatz, James H. Lan, James H. Lan, James H. Lan
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2021-09-01 |
Deskripsi
To date there is limited data on the immune profile and outcomes of solid organ transplant recipients who encounter COVID-19 infection early post-transplant. Here we present a unique case where the kidney recipient’s transplant surgery coincided with a positive SARS-CoV-2 test and the patient subsequently developed symptomatic COVID-19 perioperatively. We performed comprehensive immunological monitoring of cellular, proteomic, and serological changes during the first 4 critical months post-infection. We showed that continuation of basiliximab induction and maintenance of triple immunosuppression did not significantly impair the host’s ability to mount a robust immune response against symptomatic COVID-19 infection diagnosed within the first week post-transplant.