Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
Bedaquiline overdose: A case report
oleh: Oleksandr Telnov, Veronica Alvarez, Elena Graglia, Lucas Molfino, Philipp du Cros, Michael Rich
Format: | Article |
---|---|
Diterbitkan: | Elsevier 2019-07-01 |
Deskripsi
We present a case report describing outcomes in a 21 year old HIV-negative man who received treatment with bedaquiline. Due to error, dosage received comprised 4 pills of 100 mg every second day in the 60 days following the first two weeks of 4 pills of 100 mg every day. On detection, treatment was continued as per standard dosing of 200 mg given three times per week, with enhanced monitoring of ECG and liver function. The man was asymptomatic, with no signs of jaundice, abdominal pain, or abnormal heart rhythm. Toxic effects at this dosage were therefore not observed. Keywords: Tuberculosis, Bedaquiline, Adverse events, Therapeutic index, Tolerability