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Tuberculosis (TB) is one of the leading causes of death worldwide. Clinical features and demonstration of the organism by microscopy/culture are still the mainstay of diagnosis of tuberculosis. The present paper reviews the burden of TB and the role of serology in its diagnosis. IMC J Med Sci 2020; 14(1): 008. EPub date: 26 April 2020 Correspondence: Md. Mohiuddin, Department of Microbiology, Ibrahim Medical College, 1/A Ibrahim Sarani, Segunbagicha, Dhaka, Bangladesh, Email: mohicmc@gmail.com