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Dry eye has become one of the relatively common complications following keratoplasty due to the surgical destruction of the ocular surface and long-term application of topical eye drops. Dry eye will result in corneal epithelial defects and further could decrease the survival rate of the grafts. In order to better understand dry eye following corneal transplantation and to provide clinical guidance for physicians, we reviewed recent domestic and international published literatures regarding its pathogenesis, clinical features, prevention and management.