Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling
oleh: Jessica E. Frith, Gina D. Kusuma, James Carthew, Fanyi Li, Nicole Cloonan, Guillermo A. Gomez, Justin J. Cooper-White
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-01-01 |
Deskripsi
Mesenchymal stem cell (MSC) fate can be mechanically regulated by substrate stiffness but this is difficult to control in a 3D hydrogel. Here the authors identify miRNAs that change expression in response to substrate stiffness and RhoA signalling and show that they can bias MSC fate in a 3D soft hydrogel.