A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis
oleh: Paul Krimpenfort, Margriet Snoek, Jan-Paul Lambooij, Ji-Ying Song, Robin van der Weide, Rajith Bhaskaran, Hans Teunissen, David J. Adams, Elzo de Wit, Anton Berns
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-03-01 |
Deskripsi
Cdkn2ab knockout mice develop skin tumours but this phenotype is lost on backcrossing of the mice. Here, the authors describe a genetic variant encompassing Wnt7b that synergises with Cdkn2ab loss and is required for tumour formation in these mice.