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<strong><em>Objective(s):</em></strong> ^99mTc-PSMA SPECT/CT is a cost effective alternative for ⁶⁸Ga-PSMA PET/CT. The aim of this study was to directly compare these two techniques in patients with prostate cancer. <strong><em>Methods: </em></strong>28 man with prostate cancer were studied using ^99mTc-PSMA SPECT/CT and ⁶⁸Ga-PSMA PET/CT in a short time period (<60 days). No intervention was done between the studies. Whole body PET/CT was done 60 minutes after IV injection of 2 MBq/Kg of ⁶⁸Ga-PSMA. ^99mTc-PSMA kit (PSMA I+S) was used for SPECT/CT and whole body imaging was performed 4 hours after IV injection of 740 MBq of ^99mTc-PSMA.  Images were interpreted independently and the results of each imaging were recorded. <strong><em>R</em></strong><strong><em>esults</em></strong><em>: </em>The mean age of the patients was 64.7±9.6 years old and the mean time difference between two sets of images was 16.6±13.5 days. Abnormal uptake was seen in 25 (89.2%) patients by ⁶⁸Ga-PSMA PET/CT and 20 (71.4%) patients with ^99mTc-PSMA SPECT/CT. No patients with positive ^99mTc-PSMA SPECT/CT had negative ⁶⁸Ga-PSMA PET/CT. The mean number of detected lesions was 26.07±27.5 by ⁶⁸Ga-PSMA PET/CT and 10.52±10.99 by ^99mTc-PSMA SPECT/CT (P<0.001). Detection of lymph nodes and bone metastases were not significantly different between two sets of imaging (P>0.05), however ⁶⁸Ga-PSMA PET/CT were more successful in detection of prostate bed lesions compared to ^99mTc-PSMA scan. Interestingly, no patient with PSA level of >2.1 ng/ml had discordant result between two sets of images. <strong><em>Conclusion: </em></strong>^99mTc-PSMA SPECT/CT is as accurate as  ⁶⁸Ga-PSMA PET/CT in M staging, however ⁶⁸Ga-PSMA PET/CT detected more lesions compared to ^99mTc-PSMA SPECT/CT. Detection rate was not significantly different between two techniques in patients with PSA levels>2.1 ng/ml.