Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
oleh: Caroline Kumsta, Jessica T. Chang, Jessica Schmalz, Malene Hansen
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-02-01 |
Deskripsi
Mild heat stress has beneficial effects on organismal health and survival. Here, Kumstaet al. show that a mild heat shock and HSF-1 overexpression induce autophagy in multiple tissues of C. elegansand autophagy-related genes are essential for both heat shock-induced and HSF-1–mediated stress resistance and longevity.