The structure of an archaeal oligosaccharyltransferase provides insight into the strict exclusion of proline from the N-glycosylation sequon
oleh: Yuya Taguchi, Takahiro Yamasaki, Marie Ishikawa, Yuki Kawasaki, Ryuji Yukimura, Maki Mitani, Kunio Hirata, Daisuke Kohda
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-08-01 |
Deskripsi
Yuya Taguchi, Takahiro Yamasaki, et al. determined the crystal structure of the oligosaccharyltransferase enzyme, OST, from Aechaeoglobus fulgidus, in a complex with two substrates. Their work provides valuable insight into the sequon specificity of N-glycosylation, which is a major posttranslational modification across eukaryotes.