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Aims and Objective: A chronic obstructive pulmonary disease (COPD) is a major public health problem globally. The patients with COPD usually have dependence on society due to its nature. This study was designed to determine the health-related quality of life among COPD patients and its relationship with severity of disease. Methods: Total 54 patients were recruited through simple random sampling from the outpatient department of a tertiary care hospital. St Georges Respiratory Quality life validated structured questionnaire was used to determine the quality of life under cross sectional study design. Kruskal Wallis test, Pearson correlation and linear regression analysis were used to determine the relationship between health-related quality of life with severity of the disease. Results: The mean score of symptoms, activity, impact and total on health-related quality of life score is 60.34±12.39, 27.53±2.78, 44.98±5.08 and 23.83±2.69, respectively.. There was statistically significant positive correlation between forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and FEV1/FVC and health-related quality of life score. After adjustment of covariate in regression analysis, the variables that predicted SGRQ scores in COPD patients are age (P-value <0.04), smoking (P-value <0.01) and spirometry values (FEV1 and FVC.) (P-value <0.05). The health-related quality of life scores were significantly different among mild, moderate severe disease patients (P-value <0.05). Conclusion: Among COPD patients, the health-related quality of life was impaired, and it has decreased as severity of disease increased. Proper management of disease and improved awareness among patients regarding factors which affect the health-related quality of life among COPD patients is necessary.