Euphocactoside, a New Megastigmane Glycoside from <i>Euphorbia cactus</i> Growing in Saudi Arabia
oleh: Hanan Y. Aati, Shagufta Perveen, Jawaher Al-Qahtani, Jiangnan Peng, Areej Al-Taweel, Ali S. Alqahtani, Ali ElGamal, Giuseppina Chianese, Fahd A. Nasr, Orazio Taglialatela-Scafati, Mohammad K. Parvez
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2022-03-01 |
Deskripsi
A phytochemical investigation of the aerial parts of <i>Euphorbia cactus</i> Ehrenb. ex Boiss. revealed a new megastigmane, euphocactoside (<b>5</b>), along with eleven known metabolites. Euphocactoside (<b>5</b>) is the 3-<i>O</i>-glucoside derivative of a polyhydroxylated megastigmane showing unprecedented structural features. The structure of euphocactoside, including stereochemical details, was elucidated by extensive spectroscopic analysis based on 1D and 2D nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HR-ESIMS). The isolated compounds were evaluated for their cytotoxic activity against three different human cancer cell lines, namely, A549 (lung), LoVo (colon), and MCF-7 (breast), using MTT assay, and moderate to marginal activities were observed for compounds <b>1</b>–<b>3</b>, <b>8</b> and <b>9</b> against all three cell lines.