A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface
oleh: Kevin R. McCarthy, Jiwon Lee, Akiko Watanabe, Masayuki Kuraoka, Lindsey R. Robinson-McCarthy, George Georgiou, Garnett Kelsoe, Stephen C. Harrison
| Format: | Article |
|---|---|
| Diterbitkan: | American Society for Microbiology 2021-06-01 |
Deskripsi
The rapid appearance of mutations in circulating human influenza viruses and selection for escape from herd immunity require prediction of likely variants for an annual updating of influenza vaccines. The identification of human antibodies that recognize conserved surfaces on the influenza virus hemagglutinin (HA) has prompted efforts to design immunogens that might selectively elicit such antibodies.