MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway
oleh: Yujing Wang, Tao Wei, Wei Zhao, Zixuan Ren, Yan Wang, Yiding Zhou, Xun Song, Ruidong Zhou, Xiaochu Zhang, Dongliang Jiao
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2021-05-01 |
Deskripsi
The regulation of microRNA (miRNA) is closely related to methamphetamine (METH) addiction. Past studies have reported that miR-181a is associated with METH addiction, but the mechanism pathways remain elusive. On the basis of our past studies, which reported the endoplasmic reticulum-associated protein degradation (ERAD) mediated ubiquitin protein degradation of GABAAα1, which was involved in METH addiction. The present study, using qRT-PCR and bioinformatics analysis, further revealed that miR-181a may be indirectly responsible for the METH addiction and downregulation of GABAAα1 through the regulation of ERAD.