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The role of immune cells associated with sporotrichosis caused by <i>Sporothrix schenckii</i> is not yet fully clarified. Macrophages through pattern recognition receptors (PRRs) can recognize pathogen-associated molecular patterns (PAMPs) of <i>Sporothrix</i>, engulf it, activate respiratory burst, and secrete pro-inflammatory or anti-inflammatory biological mediators to control infection. It is important to consider that the characteristics associated with <i>S. schenckii</i> and/or the host may influence macrophage polarization (M1/M2), cell recruitment, and the type of immune response (1, 2, and 17). Currently, with the use of new monocyte-macrophage cell lines, it is possible to evaluate different host–pathogen interaction processes, which allows for the proposal of new mechanisms in human sporotrichosis. Therefore, in order to contribute to the understanding of these host–pathogen interactions, the aim of this review is to summarize and discuss the immune responses induced by macrophage-<i>S. schenckii</i> interactions, as well as the PRRs and PAMPs involved during the recognition of <i>S. schenckii</i> that favor the immune evasion by the fungus.