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This essay introduces a new analytical category of scientific actors: the methodologists. These actors are distinguished by their tendency to continue to probing scientific objects that their peers consider to be settled. The methodologists are a useful category of actors for science and technology studies (STS) scholars to follow because they reveal contingencies and uncertainties in taken-for-granted science. Identifying methodologists is useful for STS analysts seeking a way into science in moments when it is no longer “in the making” or there is little active controversy. Studying methodologists is also useful for scholars seeking to understand the genesis of scientific controversies, particularly controversies about long-established methods, facts, or premises.