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ObjectiveTo evaluate the clinical application of percutaneous injection of hemostatic agents guided by ultrasound for arresting active hemorrhage after renal biopsy. MethodsFrom January 2019 to December 2022, 10 cases of active hemorrhage after renal biopsy on ultrasound were retrospectively examined. Hemorrhage continued despite simple compression and it was treated by a percutaneous injection of hemostatic agents under ultrasonic guidance. Then hemostatic outcomes were also evaluated by ultrasound. ResultsUltrasound could detect the hemorrhagic site to enable an accurate injection of hemostatic agents. After injection, there was no active hemorrhage. ConclusionsPercutaneous injection of hemostatic drugs guided by ultrasound for arresting active hemorrhage after renal biopsy offer the advantages of rapid, accurate, effective, simple, repeatable and non-radioactive. This technique is a novel alternative for bedside immediate management of active hemorrhage after renal biopsy. At the same time, considering the safety of two kinds of hemostatic agents, hemocoagulase may be preferentially selected for local hemostasis of active hemorrhage after renal biopsy. When hemocoagulase fails to control active hemorrhage, thrombin can be replaced for hemostasis.