Challenges in identifying cancer genes by analysis of exome sequencing data
oleh: Matan Hofree, Hannah Carter, Jason F. Kreisberg, Sourav Bandyopadhyay, Paul S. Mischel, Stephen Friend, Trey Ideker
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-07-01 |
Deskripsi
Next generation sequencing has been pivotal in identifying somatic mutations in cancer samples. In this study, the authors analyse whole exome sequencing data using a variety of bioinformatic methods to identify mutations in known cancer genes and find that many cancer genes are not detected by these methods.