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This paper presents the mHealth Predictive Outbreak for COVID-19 (mPOC) framework, an autonomous platform based on wearable Internet of Medical Things (IoMT) devices for outbreak prediction and monitoring. It utilizes real-time physiological and environmental data to assess user risk. The framework incorporates the analysis of psychological and user-centric data, adopting a combination of top-down and bottom-up approaches. The mPOC mechanism utilizes the bidirectional Mobile Health (mHealth) Disaster Recovery System (mDRS) and employs an intelligent algorithm to calculate the Predictive Exposure Index (PEI) and Deterioration Risk Index (DRI). These indices trigger warnings to users based on adaptive threshold criteria and provide updates to the Outbreak Tracking Center (OTC). This paper provides a comprehensive description and analysis of the framework’s mechanisms and algorithms, complemented by the performance accuracy evaluation. By leveraging wearable IoMT devices, the mPOC framework showcases its potential in disease prevention and control during pandemics, offering timely alerts and vital information to healthcare professionals and individuals to mitigate outbreaks’ impact.