Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma
oleh: Jimyung Seo, HyunSeok Kim, Kyoung Il Min, Changgon Kim, Yongsoo Kwon, Zhenlong Zheng, Yusung Kim, Hyung-Soon Park, Young Seok Ju, Mi Ryung Roh, Kee Yang Chung, Joon Kim
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
Acral melanoma affects the soles of the feet but the etiology is unknown. Here, the authors show that melanoma cells implanted into the foot pad of mice and exposed to mechanical stress show features of nuclear rupture, DNA damage, and Yap activation.