Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
oleh: Jianquan Xu, Hongqiang Ma, Hongbin Ma, Wei Jiang, Christopher A. Mela, Meihan Duan, Shimei Zhao, Chenxi Gao, Eun-Ryeong Hahm, Santana M. Lardo, Kris Troy, Ming Sun, Reet Pai, Donna B. Stolz, Lin Zhang, Shivendra Singh, Randall E. Brand, Douglas J. Hartman, Jing Hu, Sarah J. Hainer, Yang Liu
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2020-04-01 |
Deskripsi
Aberrant chromatin structure is often found in cancer. Here, the authors optimise super-resolution microscopy for pathological tissue and discovered a significant decompaction of chromatin folding in early carcinogenesis prior to tumour formation.