Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
oleh: Chaiyaporn Kuwentrai, Jinming Yu, Li Rong, Bao‐Zhong Zhang, Ye‐Fan Hu, Hua‐Rui Gong, Ying Dou, Jian Deng, Jian‐Dong Huang, Chenjie Xu
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley 2021-01-01 |
Deskripsi
Abstract The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein contains an immunogenic receptor‐binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S‐RBD vaccine using a dissolvable microneedle skin patch can induce both significant B‐cell and significant T‐cell responses against S‐RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.