NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains
oleh: Marie-France Langelier, Levani Zandarashvili, Pedro M. Aguiar, Ben E. Black, John M. Pascal
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-02-01 |
Deskripsi
Poly(ADP-ribose) polymerases (PARPs) catalyse ADP-ribose posttranslational modifications using NAD+ as a substrate. Here, the authors present the crystal structure of PARP-1 bound to the non-hydrolyzable NAD+ analog BAD and provide insights into the mechanism of PARP-1 allosteric regulation.