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Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes.
oleh: Eriko Sasaki, Joanna Gunis, Ilka Reichardt-Gomez, Viktoria Nizhynska, Magnus Nordborg
Format: | Article |
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Diterbitkan: | Public Library of Science (PLoS) 2022-09-01 |
Deskripsi
Genome-wide association studies (GWAS) have revealed that the striking natural variation for DNA CHH-methylation (mCHH; H is A, T, or C) of transposons has oligogenic architecture involving major alleles at a handful of known methylation regulators. Here we use a conditional GWAS approach to show that CHG-methylation (mCHG) has a similar genetic architecture-once mCHH is statistically controlled for. We identify five key trans-regulators that appear to modulate mCHG levels, and show that they interact with a previously identified modifier of mCHH in regulating natural transposon mobilization.