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For tumors wherein cancer cells remain in the tissue after colorectal cancer surgery, a hyperthermic anticancer agent is injected into the abdominal cavity to necrotize the remaining cancer cells with heat using a hyperthermic intraperitoneal chemotherapy system. However, during circulation, the processing temperature is out of range and the processing result is deteriorated. This paper proposes a look-up table (LUT) module design method that can stably maintain the processing temperature range during circulation via feedback. If the temperature decreases or increases, the LUT transmits a command signal to the heat exchanger to reduce or increase heat input, thereby maintaining the treatment temperature range. The command signal for increasing and decreasing heat input is <i>T_p</i> and <i>T_a</i>, respectively. The command signal for the treatment temperature range is <i>T_s</i>. If drug temperatures below 41 and above 43 °C are input to the LUT, it sends a <i>T_p</i> or <i>T_a</i> signal to the heat exchanger to increase or decrease the input heat, respectively. If the drug’s temperature is 41–43 °C, the LUT generates a <i>T_s</i> signal and proceeds with the treatment. The proposed system can automatically control drug temperature using temperature feedback to ensure rapid, accurate, and safe treatment.