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In the title hydrated salt, C4H12NO3+·C22H25O4−·H2O, seratrodast [systematic name: 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid] crystallized with trometamol [systematic name: 2-amino-2-(hydroxyméthyl)propane-1,3-diol] to form a monohydrated salt form of seratrodast. The carboxylic acid group of seratrodast has transferred its proton to the amino N atom of trometamol. In the crystal, the trometamol cations are linked to the water molecules and to each other by N—H...O and O—H...O hydrogen bonds forming sheets parallel to (100). The seratrodast anions are linked to both sides of these sheets by O—H...O and C—H...O hydrogen bonds, forming a three-layer two-dimensional structure. After forming the title salt, the solubility of seratrodast was found to be greatly improved.