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Root canal treatment is often required when primary endodontic treatment has failed. In order to remove the root canal filling material, chemical solvents are used to solubilize the gutta-percha. Despite many advantages, these solvents can lead to mishaps when not used cautiously. The purpose of this article is to present a case report of angioedema caused due to periapical seepage of orange oil and also highlighting the preventive measures and management of such accidents in dental office.