Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
oleh: Wen-Chin Huang, Youjun Chen, Damon T. Page
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-11-01 |
Deskripsi
Dysregulation of mTOR signaling has been implicated in autism spectrum disorders. Here authors show that hyperconnectivity and hyperactivity of the mPFC–BLA circuitry inPten+/−mice underlies their social impairments, and that reducing mTORC1 signaling during early postnatal development rescues these deficits.