Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester
oleh: Antal Harsanyi, Graham Sandford, Dmitri S. Yufit, Judith A.K. Howard
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2014-05-01 |
Deskripsi
Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrates followed by decarboxylation, esterification and reductive cyclisation processes.