Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis
oleh: Chery A. Whipple, Arthur D. Lander, Murray Korc
| Format: | Article |
|---|---|
| Diterbitkan: | Hindawi Limited 2008-01-01 |
Deskripsi
The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.