Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform
oleh: Yao-Chang Tsan, Samuel J. DePalma, Yan-Ting Zhao, Adela Capilnasiu, Yu-Wei Wu, Brynn Elder, Isabella Panse, Kathryn Ufford, Daniel L. Matera, Sabrina Friedline, Thomas S. O’Leary, Nadab Wubshet, Kenneth K. Y. Ho, Michael J. Previs, David Nordsletten, Lori L. Isom, Brendon M. Baker, Allen P. Liu, Adam S. Helms
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-10-01 |
Deskripsi
Investigations of human cardiac disease involving human pluripotent stem cell-derived cardiomyocytes are limited by the disorganized presentation of biomechanical cues resulting in cell immaturity. Here the authors develop a platform of micron-scale 2D cardiac muscle bundles to precisely deliver physiologic cues, improving reproducibility and throughput.