Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons
oleh: Min-Min Lou, Xiao-Qiang Tang, Guang-Ming Wang, Jia He, Fang Luo, Ming-Feng Guan, Fei Wang, Huan Zou, Jun-Ying Wang, Qun Zhang, Ming-Jian Xu, Qi-Li Shi, Li-Bing Shen, Guo-Ming Ma, Yi Wu, Yao-Yang Zhang, Ai-bin Liang, Ting-Hua Wang, Liu-Lin Xiong, Jian Wang, Jun Xu, Wen-Yuan Wang
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-07-01 |
Deskripsi
Long noncoding RNAs (lncRNAs) are known to regulate the DNA damage response (DDR), however their role in the brain is less well studied. Here, the authors demonstrate a neuron-specific role for Brain Specific DNA-damage Related lncRNA1 (BS-DRL1) and show BS-DRL1 modulates DDR by interacting with HMGB1 in a cell-type specific manner.