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At present, osteoporotic fractures are the functional as well as an economic challenge for the patient, and these are equally challenging for the surgeon to manage them. However, nowadays most of the clinical settings are biologically optimized to enhance the bone regenerations, but still many patients continue to experience impaired healing of various origins. Autologous bone grafting remains the standard biological procedure to treat these impaired healing against which all the novel technologies are compared. The osteoporotic fracture healing undergoes the same stages of healing except that, they are slow in progress and takes a longer period of healing than the normal bone healing. As the fracture healing initiates with the formation of fracture clot, several investigators have suggested that degranulation of platelets at fracture clot elaborates the bioactive component, especially the growth factors that are essential for the bone formation. Because autologous platelet-rich plasma (PRP) products are safe and easy to prepare and administer, in the present review, we highlight the role of bioactive component released by activated PRP in the fracture healing process complicated by osteoporosis.